The plot of the novel is based around the discovery within Roman ruins of a new gospel written by Jesus' younger brother, James in the first century.

However, as Steven gets more involved in the project he runs into several questionable circumstances, as radical clerics centered in Central Europe oppose the publication of the document, since it would give ammunition for the conservative churches to keep the flow of worship from the top to the bottom, instead of bringing the faith to the masses.

A struggle for control of the World Council of Churches, the suspicious absence in the project of archeologist Prof. Augusto Monti, the original discoverer – and whose daughter Angela is a potential love interest for Steve – and the potential notion that the newly discovered gospel itself is a forgery made in the 20th century instead of a legitimate historical document, all are guaranteed to make Steve question the worth of the new job he is undertaking, and the newly re-found faith in God he acquired along with it.

Wallace touches on several topics related to the origin of the Bible, and current issues of Christianity, while writing the book: The Word was a New York Times best seller.

It starred David Janssen as Steven, Kate Mulgrew as Steven's first lover Darlene (renamed Tony in the TV version), Florinda Bolkan as Angela, James Whitmore as George Wheeler, Eddie Albert as Ogden Towery, Geraldine Chaplin as Naomi Dunn, Hurd Hatfield as Cedric Plummer, John Huston as Nathan Randall, John McEnery as Florian Knight, Ron Moody as LeBrun, Diana Muldaur as Claire Randall, Janice Rule as Barbara Randall, Martha Scott as Sarah Randall, Nicol Williamson as Maertin de Vroome, and Mario Scaccia as Prof. Monti.