The series centers on a nuclear family of four highly trained spies who must conceal their identity from the outside world but normally having trouble in doing so.

(short for Society of Nefarious and Felonious Undertakings) led by the evil Glowface is continually trying to cause trouble for the X's and other SUPERIOR agents through their plans to take over the world.

The location of the show is in a coastal city, likely somewhere in the United States, as Mr. and Mrs. X have used the country's currency in the episodes "Secret Agent Manual", "Wealth vs. Stealth", and "Train Rex".

His longtime work partner John Kricfalusi makes a cameo appearance in an episode, despite defaming the production company at its earliest years.

After production wrapped in late 2006, Carlos Ramos and director Dave Marshall moved on to work on Ni Hao, Kai-Lan's pilot and series.

[8][9] CG Supervisor Ernest Chan, along with voice-director and writer, Doug Langdale, moved to providing 3D special effects and writing episodes of El Tigre: The Adventures of Manny Rivera respectively.

The final episode, "Theater of War" / "Breaking Camp", remains unaired in the United States, but was aired in Europe and Asia.

As confirmed by Carlos Ramos on Tumblr, he had written an episode in December 2005 titled "Bro Face", which would have been about Glowface's brother coming to visit him.