Dorsal skin is covered with calcified, white-tipped asperities, forming cluster especially near the tympana and along the dorsolateral region.

[3] Theloderma phrynoderma occurs in both lowland and montane wet evergreen forest as well as evergreen mixed deciduous and bamboo forest at elevations of 59–2,400 m (194–7,874 ft) above sea level.

Reproductive behaviour is unknown, but presumably this species deposits its eggs in small bodies of standing water, such as water-filled tree holes or rock depressions.

[1] This species is known from few specimens, but it is not clear whether it is genuinely rare or simply difficult to detect.

[1] The recently collected specimens are from a protected area (Tanintharyi Nature Reserve).