Born in Kozani, Greece, Tzimopoulos began his professional career with Akratitos in December 2003, having previously signed as a trainee.
[4] On 6 April 2017, Tzimopoulos had a surgery on the knee to restore meniscal tear suffered, and will naturally lose the remainder of the current season.
[8] Tzimopoulos was called into the All Whites squad for a 31 March 2015 friendly in Seoul against South Korea by coach Anthony Hudson.
[9] On 28 May 2016, with an early goal from Tzimopoulos, the All Whites got off to a winning start at the OFC Nations Cup after a hard-fought and physical 3–1 victory over Fiji.
[10] Tzimopoulos' exceptional season year with PAS Giannina was his passport to be called up by Hudson to the final 23-man squad for the 2017 Confederations Cup.