[4] Before her election to the European Parliament, Comodini Cachia helped represent the Nationalist Party in a constitutional case against the Maltese Electoral Commission regarding disparity in the vote-counting process in the general elections of 2013 [5] After a mistake in vote counting was challenged in court, she helped advocate for the PN during the lengthy and detailed legal process.

[7] In addition, she was a substitute member of the Subcommittee on Human Rights (DROI), the Committee on Culture and Education (CULT), and the delegation for relations with the People's Republic of China.

[12] On 9 July 2020, Comodini Cachia was nominated to head the Nationalist Party, after the incumbent leader, Dr. Adrian Delia, lost a no confidence vote.

[citation needed] Comodini Cachia has presented her research and reports on subjects related to human rights (focusing on Malta) to multiple European institutions.

She contributed to various publications of the Fundamental Rights Agency (FRA) of the European Union with a variety of works on trafficking of minors, racism, xenophobia, discrimination, protection of information, mental health, illegal immigration, and repatriation.

Comodini Cachia presented reports on discrimination at work, on the basis of race, belief, or sexual orientation.

[15] In March 2016, Comodini Cachia was named MEP of the Year by The Parliament Magazine in the field of corporate governance.

[16] The award was her first in Brussels, and the magazine stated that "Comodini Cachia has been praised for the enthusiasm and passion she brings to her work.