MacDonald reported that "Thessalon" is a corruption of a name given by local First Nations, Neyashewun, meaning "a point of land".

It is also theorized that the town may have been named by Jesuit missionaries who compared their travels through the region to the plight of the Thessalonians described in the Pauline epistles.

Fishing is excellent in the river: yellow perch, pickerel, bass, northwater salmon and muskie.

[6] Population trend:[9][10][1] Ontario Northland provides intercity motor coach service to Thessalon as a stop along its Sault Ste.

Marie–Sudbury–North Bay–Ottawa route, with one bus a day each headed eastbound and westbound from Sunday to Friday, with no service on Saturdays.