Surgeon Lieutenant Seward arrives at the post with the wife of Colonel Waters, commanding the regiment, and his flirtatious niece Laurie.

Waters and Captain Peter Blake are concerned with recovering ten stolen repeating rifles and preventing the so-far-peaceful Kiowa from leaving their reservation to join up with the warlike Comanche.

Doctor Seward accompanies Blake to the reservation to recover the rifles and meets a white woman who has become Manyi-ten, and the tribal medicine man, Isatai, gaining compassion for the Kiowa.

An angry Colonel Waters at first places him under house arrest but then sends him on a combat patrol that is ambushed when the two tribes combine against them.

Seward leaves the post to persuade Isatai into making peace but Blake follows in the dark to kill him as a traitor.