Thierry was born in Laos on April 23, 1958, to a Sino-Thai father, Anek Mekwattana (เอนก เมฆวัฒนา), who worked for the United States's CIA (with the delivery of military equipment to the US Army), and a Swiss mother.
Later, when a coup in Laos in 1960 occurred, Anek led his family to settle in Thailand permanently.
He entered the entertainment industry in the late 1970s to early 1980s as a model and actor, he acted round about 2–3 films as a lead role character.
His famous singles with Carabao are Naang Ngaam Tuu Kracok (นางงามตู้กระจก) in the fifth album Made in Thailand in December 1984 and Mae Sai (แม่สาย) in the ninth album Thap Lang in November 1988, both of them have content about the issue of prostitution in Thailand.
His character was represented by Chulachak "Hugo" Chakrabongse and his own childhood, acted by his son Mek "Jessie" Mekwattana.