[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.
[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine.
The drug enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.
Its action on H3 receptors is thought to promote wakefulness and improve memory consolidation.
This drug article relating to the nervous system is a stub.