Third Avenue is a north-south thoroughfare on the East Side of the New York City borough of Manhattan, as well as in the center portion of the Bronx.

It is one of the four streets that form The Hub, a site of both maximum traffic and architectural density in the South Bronx.

In May 1861, according to a letter to the editor of The New York Times, the street was the scene of practice marching for the poorly equipped troops in the 7th New York Volunteer Infantry Regiment: "The men were not in uniform, but very poorly dressed, — in many cases with flip-flap shoes.

"[4] On July 17, 1960, the section of Third Avenue in Manhattan north of 24th Street was converted into a one-way road.

In Manhattan, several crosstown subway routes have entrances on Third Avenue: Notes Bibliography