The Third Upper Peru campaign was an unsuccessful invasion by the rebel United Provinces of the Río de la Plata, in 1815 during the Argentine War of Independence, of Upper Peru (today Bolivia), which was still under control of Spanish troops.

The Northern Army, unofficially commanded by José Rondeau, started another campaign, but this time without the authorization of Supreme Director Ignacio Álvarez Thomas.

After a successful battle in April 1815 at Puesto del Marquéz, near today's border between Bolivia and Argentina, Rondeau's army reached Potosí by June and Chayanta by September.

In October, an attempt to overrun a small Royalist garrison at Venta y Media ended in defeat.

Pezuela now launched a counteroffensive against Rondeau, and inflicted a crushing defeat in the Battle of Sipe-Sipe (or Viluma) on 28 November.