It premiered on 5 November 2007 and initially aired weekday afternoons on Sun TV, before being moved to 8PM on 1 December 2008.

Thirumathi Selvam is currently re-airing on Kalaignar TV from 29 March 2021.

The story revolves around the lead character Selvam and showed how his good qualities, hard work, and love for his wife Archana and care for his best friend Nandhini and how that made him reach great heights.

The serial was remade in Hindi as Pavitra Rishta[2] under Balaji Telefilms, which aired on Zee TV, and in Malayalam as Nilavilakku which aired from 2009 to 2013 on Surya TV.

Thirumathi Selvam had a crossover with Thendral as a special episode on 1 May 2011.