During Brinkley's run, three major sponsors were part of the show: General Electric (which departed after taking control on NBC in 1987), Archer Daniels Midland and Merrill Lynch.

[7] Longtime panelist George Stephanopoulos became the new host of This Week on September 15, 2002;[8] he ended his first tenure with the program on January 10, 2010, shortly after being named the co-host of Good Morning America.

ABC News Senior White House Correspondent Jake Tapper served as the interim anchor from March to July 2010.

[12] With the return of Stephanopolous as moderator, the program began using former Good Morning America and World News Tonight anchor Charles Gibson to perform the voice-over heard during the opening of each broadcast;[13] this lasted until 2014.

Will, a regular panelist who was with the program from its launch with David Brinkley until he left ABC to join Fox News as a contributor in 2013,[15] sometimes contributed short reports to the broadcast.

After George Stephanopolous became host in 2002, new segments were added to the program including: In 2010, Jake Tapper arranged with Bill Adair to get PolitiFact.com to fact check the statements made by panelists and guests featured on This Week.

Recurring panelists have included George Will, Cokie Roberts, Sam Donaldson, Bill Kristol, Fareed Zakaria, Martha Raddatz, Peggy Noonan, Victoria Clarke, Donna Brazile, Ann Coulter, Paul Krugman, Jay Carney, Claire Shipman, E.J.