Thomas Ara Spence (February 20, 1810 – November 10, 1877) was an American politician.
He graduated from Yale College in 1829, studied law, and was admitted to the bar, commencing practice at Snow Hill, Maryland.
Spence owned large iron-ore properties in Worcester County, Maryland, and served as a judge for Worcester County and the twelfth judicial circuit from 1857 to 1867.
He practiced law in Salisbury, Maryland, and served as assistant attorney general for the Post Office Department from 1872 until his death in Washington, D.C..
He is interred in Makamie Memorial Church Cemetery in Snow Hill.