He began his acting career in theater in 1923, studying under actor Walter Hampden in a production of Cyrano de Bergerac in Syracuse, New York.

A frequent performer on television, Gomez also appeared in guest roles in such series as The Twilight Zone, Route 66, Dr. Kildare, Mr. Ed, Burke's Law, The Virginian, It Takes a Thief, Bewitched, The Rifleman, and Gunsmoke.

Billboard lauded the "humanity and finely effective detail of his character work" in the short-running 1942 Broadway play The Flowers of Virtue.

[3] In 1956, he replaced Burl Ives as Big Daddy in the original Broadway production of Tennessee Williams's Cat on a Hot Tin Roof.

[1] Thomas Gomez died at St. John's Hospital in Santa Monica, California, aged 65, after 3 weeks in a coma related to injuries sustained in a car accident.