Thomas Holdsworth Blake (June 14, 1792 – November 28, 1849) was an American politician who served as a United States Representative from Indiana from 1827 to 1829.

On May 19, 1842, President Tyler appointed him as Commissioner of the General Land Office; he served until April 1845.

In later years, he was a resident trustee of the Wabash & Erie Canal, and he also visited England as a financial agent of the state of Indiana.

While returning from that trip, he died in Cincinnati, Ohio, on November 28, 1849, and was interred in Woodlawn Cemetery, in Terre Haute.

This article incorporates public domain material from the Biographical Directory of the United States Congress "Blake, Thomas Holdsworth" .