Thomas George Hupke (December 29, 1910 – September 8, 1959) was an American football player.

During the four years Hupke played for the Crimson Tide, the team compiled a record of 34–4–1.

He subsequently played professional football for six years with the Detroit Lions (1934–1937) and the Cleveland Rams (1938–1939).

He was a member of the 1935 Detroit Lions team that won the 1935 NFL Championship Game.

In September 1959, Hupke died in Detroit at age 48 after a long illness.