There, he produced the first American long-term mortality studies and showed how social security data could be used to understand deaths among factory workers.
[3] There he was influenced by National Cancer Institute's Wilhelm Hueper, and produced the first American long-term mortality studies on occupational groups, using social security data.
[5][6] During his time at Ohio, he showed cancer-causing effects of several chemicals including aromatic amines, cadmium, hydrogen sulphide, manganese, and mercury.
[3][4] In 1964, the Division of Biology and medicine of the Atomic Energy Commission (AEC) asked Mancuso of the possibility of long-term effects of low levels of ionising radiation.
[6] The following year they granted him a five-year contract to investigate the effects of low-level radiation on half a million workers employed in a nuclear weapons plant.
[6][11] In 1977 they revealed that Hanford Nuclear Weapons Plant employees were "dying of cancer from cumulative radiation exposures far below the standards established as safe".
[14] In a 1972 paper, Mancuso had traced employment records from 1938 at the Industrial Rayon Corporation, to study neuropsychiatric effects of carbon disulfide, used in producing viscose.
[16] In 1974 Mancuso was a consultant for the International Association of Machinists and Aerospace Workers, and gave its members advice on how to keep themselves safe from occupational hazards.