[3] Mesereau represented former world heavyweight boxing champion Mike Tyson in a rape investigation conducted by the San Bernardino County, California District Attorney's Office in 2001.

[4] Mesereau was the second lawyer during pre-trial proceedings in actor Robert Blake's case[5] for the murder of his wife Bonnie Lee Bakley.

[9] In 2004, Mesereau and Susan Yu were hired to replace attorneys Mark Geragos and Ben Brafman as lead trial counsel.

[12] In an unusual pretrial hearing, Mesereau called Santa Barbara County District Attorney Thomas Sneddon to the witness stand and examined him under oath.

[17] On April 9, 2012, Mesereau and Yu began jury selection in their defense of Claudia Haro, the ex-wife of Oscar-winning actor Joe Pesci.

[18] The Los Angeles County District Attorney's Office claimed that Haro masterminded numerous attempts to murder her next husband, Garrett Warren, a stuntman who appeared in the movies Mission Impossible III, Avatar and Iron Man 2.

After the start of jury selection, Haro pleaded "no contest" to two counts of attempted murder with a sentence of twelve years, four months.

[citation needed] On May 30, 2015, Mesereau was retained by rap mogul Marion "Suge" Knight, founder of Death Row Records.

[20][21] Schwartz and colleague Thaddeus Culpepper were later replaced by criminal defense attorneys Antoine D. Williams, Jamal Tooson, and Jeremy Lessem on May 9, 2016, as well.

[25][26][27][28][29] He has established a legal clinic in Los Angeles and accepts one capital murder case each year on behalf of a defendant in the Deep South who cannot afford representation.