The Thomas Sully Residence is a historic rowhouse at 530 Spruce Street in Philadelphia, Pennsylvania, USA.

It was briefly (1828–29) a home of painter Thomas Sully (1783-1872), who lived in Philadelphia for the last 64 years of his life.

[4] It is one of many homes occupied by the painter Thomas Sully during sixty-four years of residence in the city.

Although he was born in England, Sully came to the United States as a child in 1792, and became one of the nation's most prolific painters of the first half of the 19th century, producing more than 2,600 works in his long career.

After living in Charleston, South Carolina and New York City, Sully came to Philadelphia in 1808.