1403) of Sydenham), upon his marriage to Margaret Brett (alias Brit),[8] daughter and heiress of Robert Brett of Staddiscombe, near Plymstock,[9][10][11] lord of the manor of Stoke Damerel.

[12][13] In 1621 he was elected a member of parliament for Bere Alston[2] in Devon, where he had gained influence following local land purchases.

[6] He re-built Sydenham House and added such height and such a great amount of stone to it that his contemporary Risdon (died 1640) described Sydenham as: He also built a new mansion house on his ancestral estate at Stoke Damerel, which he named Mount Wise,[15] on a headland jutting out into Plymouth Sound.

His contemporary the Devon historian Sir William Pole (died 1635) remarked as follows concerning the manor of Stoke Damerel and Sir Thomas Wise: In about 1600[12] Wise married Margery Stafford (born 1583), daughter and sole heiress of Robert Stafford (died 1604)[16] of Stafford (alias Stoford) in the parish of Dolton in Devon.

By his wife he had children as follows:[12] Wise died in 1630 and was buried in Marystow Church, where survives his "splendid"[6] marble monument with eight Corinthian columns surrounded by other monuments to the Wise family.