He was the fourth of six sons of a Salford Unitarian cotton merchant, also called Thomas, and his second wife Susanna (1792–1869).
On the suspension of this work in 1848, he went on an eight-month study tour to France, Italy and Switzerland accompanied by a friend, Henry A.
[3] Their journey took them through Tuscany, Latium and Campania; Worthington's notes and sketches from the trip provided him with a first-hand knowledge of Italian Gothic and Renaissance architecture, which give him inspiration for his own later work.
[2][4] After returning to Manchester in October 1848, Worthington spent a short time gaining experience of quantity surveying, before opening his own architectural practice in King Street the following year.
[4] Thomas Worthington lies buried at the churchyard of the Victorian gothic Brookfield Unitarian Church, Gorton, Manchester.