Thomas Worthington (July 16, 1773 – June 20, 1827) was an American politician who served as the sixth governor of Ohio.

[1] In 1796, he married a Virginia woman, Eleanor Swearingen, who joined him in emigrating to Ross County, Ohio, where they emancipated their slaves.

[citation needed] The first of their ten children, daughter Mary, married David Macomb, a future leader of the Texas Revolution.

[7] He narrowly lost a bid for a partial term in the Senate in 1821, losing to the incumbent governor, Ethan Allen Brown, and so he instead returned to the Ohio House of Representatives.

Worthington was initially buried at his estate in Adena, and was later interred at Grandview Cemetery, Chillicothe, Ross County, Ohio.