The Thomasville Historic District is a historic district in the city of Thomasville, Alabama, United States.

Thomasville was founded in 1888, along the then newly constructed railroad between Mobile and Selma.

The city's business district suffered a major fire in 1899, with only one brick building surviving.

[2] The historic district features examples of early commercial, Queen Anne, Colonial Revival, Craftsman, and regional vernacular architecture.

It is a part of the Clarke County Multiple Property Submission and was placed on the National Register of Historic Places on February 12, 1999.