Thompsonville is a census-designated place (CDP) and unincorporated community in Jim Hogg County, Texas, United States.

The CDP takes its name from an unincorporated community near the western border of Jim Hogg County, at the junction of Farm Roads 649 and 3073, 9 miles (14 km) west of the Thompsonville CDP and 18 miles (29 km) southwest of Hebbronville.

According to the Handbook of Texas, the community was probably named after Jim Hogg County's first sheriff, Oscar Thompson.

The well was located in the Mirando Valley field near Thompsonville and brought new residents to the area.

This article about a location in Jim Hogg County, Texas is a stub.