Thong Saen Khan (Thai: ทองแสนขัน, pronounced [tʰɔ̄ːŋ sɛ̌ːn kʰǎn]) is a district (amphoe) in the southern part of Uttaradit province, northern Thailand.

Neighboring districts are (from the southwest clockwise) Phichai, Tron, Mueang Uttaradit, Tha Pla, Nam Pat of Uttaradit Province, Chat Trakan and Wat Bot of Phitsanulok province The minor district (king amphoe) was created on 1 July 1983, when four tambon were split off from Tron district.

[2] The district is divided into four sub-districts (tambons), which are further subdivided into 45 villages (mubans).

The township (thesaban tambon) Thong Saen Khan covers parts of tambon Bo Thong.

This Uttaradit province location article is a stub.