The M4 (London-South Wales Motorway) in this area was opened in December 1964, from junctions 4 (A408) to 5; this 3.9-mile section cost £3.2m, and was built by Cubitts and Green.

The southern part of the M4/M25 interchange was part of a 2.05-mile section of the M25 which was due to open in spring 1985, the Poyle to Thorney Mill Road section, from junction 14 (Poyle Interchange) to junction 15.

At the time of opening two sections of the M25 remained to be completed in Hertfordshire and Kent (which opened in February 1986), and the M4/M25 junction was expected to be the busiest motorway junction in the UK.

The part of the interchange that is south of the M4 is in Colnbrook with Poyle, in Slough.

A single-track railway line passes through the middle of the interchange from north to south.

[7] The only remaining section of the former Staines and West Drayton Railway, it carries freight to the Lakeside industrial estate south of the interchange,