Unlike its preceding singles "Jerry Was a Race Car Driver" and "Tommy the Cat", "Tweekers" did not feature an accompanying video.
The song opens with Larry LaLonde on guitar and a reserved bassline from Les Claypool, from there alternating between his trademark slap bass and a quiet section for the vocals.
The song's narrative describes several different trades that the town's blue collar tweekers engage in, but, like many of the other story-telling songs in Primus's catalogue, lacks any clear, single meaning and leaves plenty of ambiguity in its lyrics.
He’d snort up speed to keep up with the younger guys.When performing live, Claypool changed a particular word in the lyrics.
A live version of the song (performed at Primus' show at the Brixton Academy, London, England on July 13, 2011) also appears as an iTunes exclusive bonus track on the band's 2011 album, Green Naugahyde.