[4] Catherine Jensen, a recently promoted homicide detective, enlists the help of Thomas Schaeffer, a forensic psychologist, to track down serial killers and relentlessly seeks the truth behind the disappearance of her brother that she thinks is linked to his stepfather, Judge Howard Burgess.

In January 2012, the A&E television channel announced that it had bought the rights to develop a U.S. version of the Danish series, Those Who Kill.

[5] A pilot episode began filming in Pittsburgh in December 2012, produced by Fox 21 and written by Glen Morgan, with Chloë Sevigny starring as Pittsburgh Police homicide detective Catherine Jensen, and James D'Arcy as forensic psychologist Thomas Schaeffer.

Producers selected locations such as warehouses, parking garages, pubs, hospitals, theaters, penitentiaries, the Allegheny County Courthouse, Riverview Park, the Carnegie Free Library of Allegheny, and the abandoned Carrie Furnace to capture the mood of the series.

The site's consensus is, "In spite of its suspenseful premise and an effective performance by Chloë Sevigny, Those Who Kill is bogged down by monotonous plots and senseless violence.