The bank itself is sometimes known as 'the Old Lady of Threadneedle Street' and has been based at its current location since 1734.

The London Stock Exchange was situated on Threadneedle Street until 2004, when it relocated to nearby Paternoster Square.

The Baltic Exchange was founded in the Virginia and Baltick Coffee House on Threadneedle Street in 1744.

Reportedly the British national anthem was sung, in private, in 1607 for the first time, conducted by John Bull.

Over 5,000 tonnes of gold bars are held by the Bank of England, both official reserves of the UK Treasury, and others, in a system of eight vaults, over two floors, under Threadneedle Street.