Years before the online incarnation, Three-Lobed Burning Eye was an independent literary magazine founded by Fuller and his friend Matthew Duncan while attending Bowling Green State University as creative writing students.
Publishing frequency has changed from the original quarterly schedule, to triannual, to "2–3 times per year," with a few unintentional hiatuses, which have made the print anthologies less than annual.
Early issues featured stories by Gemma Files, D. F. Lewis, Laird Barron, Tim Waggoner, and Kealan Patrick Burke.
More recent issues have included fiction by Adam Browne, Lida Broadhurst, Nadia Bulkin, Cody Goodfellow, J. M. McDermott, Darren Speegle, Edward Morris, and Shweta Narayan.
The first fifteen issues and four annuals included an art gallery, and featured award-winning artists like Joachim Luetke, David Ho, and Alessandro Bavari.