Three Rivers is an American medical drama television series that aired on CBS from October 4, 2009, to July 3, 2010, and starred Alex O'Loughlin in the role of a famous transplant surgeon in Pittsburgh, Pennsylvania.

[1][2][3] On November 30, 2009, after just eight episodes of the season had aired Sunday at 9:00 pm (EST), CBS announced that Three Rivers had been pulled from its schedule with no plans to have it returned,[4] and the series was later officially cancelled.

[6] With the long-running NBC drama ER coming to an end, CBS executives put out a call for a new medical show to fill the void.

[9] Post-pilot recasting resulted in actors Julia Ormond and Joaquim de Almeida departing and Alfre Woodard and Amber Clayton joining the series.

A high-tech, more visually appealing hospital set for the ER and ICU was built on sound stages 19 and 20 at Paramount Pictures, where interior scenes were thereafter produced, although location shooting still occurred in Pittsburgh for exterior shots.