Jagger calls three dominatrixes: The Countess (Pamela Serpe), The Empress (Irene Tsu), and The Princess (Marie O'Henry).

Their chief scientist, Dr. Fortrero (Richard Angarola), has developed a lethal poison that only affects African Americans.

They plan to deploy the serum into the water systems of Washington, D.C., Detroit, and Los Angeles, in order to wipe out their black populations.

[citation needed] I'm Gonna Git You Sucka (1988) includes a gag where Jim Brown, in a supporting role, never reloads his gun, same as the characters he and Williamson play in Three the Hard Way.

In Undercover Brother (2002), Eddie Griffin portrays a soulful crime-fighting vigilante who must stop the white-run "Man" before he destroys the black population of the United States through an ingested toxin.

Performed by Curtis Mayfield's former group The Impressions, the soundtrack featured the songs "That's What Love Can Do" and "Three the Hard Way" plus "Make a Resolution".