[3] TAT is formed in response to the high thrombin level caused by coagulation following a ruptured vessel.
Thrombin can pass the blood–brain barrier, destroying neurons and potentially causing cerebral edemas.
[5] TAT levels were studied in patients with intracranial blood clot removal within 24 hours after intracerebral hemorrhage (ICH) in Fujian from 2006 to 2008.
The TAT levels correlate with the severity of ICH according to GCS and NIHSS, and so, the study concluded that TAT complex may be useful in the prognosis for post-operative ICH-patients.
[4] TAT levels are increased with pregnancy[6] and by ethinylestradiol-containing birth control pills.