Thug Brothers is a collaborative studio album by American rappers Layzie Bone of Bone Thugs-n-Harmony and Young Noble of the Outlawz.

It was released on February 7, 2006 via Real Talk Entertainment.

A sequel album Thug Brothers 2 was released in 2017 which is a collaborative effort by Krayzie Bone and Young Noble, Krazie Bone picks up where Layzie Bone left off.