Born in Mapetla, Soweto, Serero is a product of the Ajax Cape Town's youth academy having been promoted to the first team in 2008, making his debut under then head coach Craig Rosslee.

Ajax CT would finish in 7th place again that season, with Serero gaining much attention from the local media for his performances on the pitch.

On 1 September 2013 Serero made his debut in the starting 11 of Ajax, replacing Christian Eriksen who had just left for Tottenham Hotspur, playing in the midfield.

On 5 August 2013, he made his debut in the Eerste Divisie, playing for the reserves team Jong Ajax, who had recently been promoted.

[14] He was released from the national team squad due to disciplinary reasons the day before their 2014 World Cup qualification group match against Botswana on 7 September 2013.

[15] According to Gordon Igesund, Serero had allegedly stated to the team doctor that he did not want to play in the match in order to avoid risking an injury ahead of an upcoming UEFA Champions League game for his club.

[17] On 15 November 2014, Serero scored his first goal for the South African senior team in a 2015 Africa Cup of Nations qualification match against Sudan, scoring in the 37th minute of the 2–1 win at home, thus helping his team secure a berth in the final tournament held in Equatorial Guinea the next year.