Ticked-Off Trannies with Knives is a 2010 American rape and revenge exploitation film written and directed by Israel Luna.

The film follows a trio of trans women who exact revenge on the men who brutally assault them and murder two of their friends.

The Gay & Lesbian Alliance Against Defamation (GLAAD) condemned the film for what it called a negative portrayal of transgender people.

After performing at a local club, trans women Rachel Slurr and Emma Grashun plan to party with Nacho and Chuey.

Emma and Rachel are severely wounded but Bubbles is able to call her "mother" Pinky La'Trimm and Tipper Sommore and escape.

Boner regains consciousness to learn that the women have placed switchblade knives in the rectal cavities of Nacho and Chuey and a gun in his own rectum, weapons that will be triggered if any of them make any sudden moves.

[2] The idea for his self-described "transploitation" film came while he and a group of friends were watching Robert Rodriguez and Quentin Tarantino's Grindhouse.

Writing for Variety, John Anderson compared Ticked-Off Trannies to the works of Roger Corman, Quentin Tarantino, and Robert Rodriguez.

Finding that the film has a "transgressive edginess", Anderson noted the "catch-22" that Luna created for himself in balancing its championing of transgender people with its exploitation of their "inherently funny" nature.

Anderson concludes that Luna is for the most part successful in creating solid characters but that the film descends into the realm of cartoon violence.

[7] Conversely, Frank Scheck for Reuters found the film "more than lives up to its title", although it would "probably [be] best appreciated at a midnight showing".

[11] Lead actress Krystal Summers responded to the controversy, saying in part "Our film does not promote hate or violence against transgender women.