She played college basketball at the University of North Carolina and attended T. C. Williams High School in Alexandria, Virginia.

[1][2] Source[3] Ruffin-Pratt joined the Washington Mystics training camp roster in May 2013 after going undrafted in the 2013 WNBA draft.

[2][4] In her rookie season, she played 34 games off the bench and averaged 4.4 ppg That year the Mystics made the playoffs finishing 3rd place in the Eastern Conference with a 17–17 record but were eliminated 2–1 in the first round by the Atlanta Dream.

[5] The Mystics made the playoffs finishing 4th place in the Eastern Conference with an 18–16 record and were a first round exit yet again as they were defeated 2-1 by the New York Liberty.

In the 2016 season, Ruffin-Pratt moved to small forward in the Mystics starting lineup in order to make room for Tayler Hill at shooting guard.

In the semi-finals, the Mystics defeated the Atlanta Dream in five games to advance to the WNBA Finals for the first time in franchise history.

Ruffin-Pratt started in 33 of the 34 games played during the season, the Sparks finished 22–12 with the number 3 seed, receiving a bye to the second round.