Tierra de Léon is a Spanish Denominación de Origen Protegida (DOP) for wines located in the south of the province of León, in Castile and León, Spain, and covers an area of 3,317 km2 at an altitude of approximately 900 m above sea level.

The area benefited from being at the crossroads of two important routes: The Way of Saint James, the pilgrimage route running east to west from France to Santiago de Compostela, and the Ruta de la Plata, running north–south between the silver mines of the Cantabrian coast and the southern port of Cadiz.

Around the 10th century, the main economic activities of the region were cereal production and milling, along with grape growing and winemaking, which was practiced in the monasteries of different religious orders.

In 1985, a group of producers applied for DO status based on the promotion of the local autochthonous grape variety known as Prieto Picudo.

The area has a continental climate (long, hot dry summers; cold winters).