Tillabéri is a department of the Tillabéri Region in Niger.

Its capital lies at the city of Tillabéri, and contains the Communes of Ayorou (as of 2001 the largest town in Department), Anzourou, Dessa, Kourteye, and Sinder.

The western border of the department is formed by the Niger River.

As of 2012, the department had a total population of 227,352 people.

This Niger location article is a stub.