Tillatoba is a town in Yalobusha County, Mississippi, United States.

Agricultural products produced by the town include cotton, corn, poultry, cattle, and timber.

[2] According to the United States Census Bureau, the town has a total area of 1.0 square mile (2.6 km2), all land.

As of the 2020 United States census, there were 95 people, 26 households, and 12 families residing in the town.

There were 13.7% of families and 10.1% of the population living below the poverty line, including no under eighteens and none of those over 64.