It was built in 1894, and is a three-story, red brick building in the Richardsonian Romanesque style.

The building includes a basement and attic, has a combination gabled and hipped roof configuration, projecting bay windows, and features a conical-roofed clock tower with open belfry.

[2][3] Tillman Hall's Auditorium has hosted concerts by Frankie Valli and the Four Seasons in 1970, Jars of Clay in 1997, Florida's metal band Trivium in 2005, Celtic rock band Seven Nations in 2005, Recycled Percussion in 2007 and 2003, and pop folk pianist Vienna Teng in 2008.

[1] On June 19, 2020, Winthrop University's board of trustees passed unanimously a resolution requesting South Carolina state legislators to consider amending the Heritage Act of 2000 to "allow Winthrop to restore Tillman Hall to its original name of Main Building.

This article about a property in York County, South Carolina on the National Register of Historic Places is a stub.