Alexander has played in several projects with Tool frontman Maynard James Keenan including the bands Puscifer and A Perfect Circle.

[4] Alexander has played on the majority of Primus's discography, including some of the band's most well known albums such as Frizzle Fry (1990), Sailing the Seas of Cheese (1991), Pork Soda (1993) and Tales from the Punchbowl (1995).

On April 21st, 2024 he released an album titled "All That Syncs Must Diverge" with saxophonist Skerik and bassist Timm Mason, under the name Sound Cipher.

[6] On September 25, 2013, Rolling Stone announced via an interview with Claypool that Alexander would be rejoining Primus, with a possible recording session taking place as early as November.

[11] Tim has stated that his reasons for leaving Primus again, while on tour in October of 2024, were due to ongoing health issues and to be closer to his family.