[5] From the age of four, Chris helped his son refine his pitching motion, filming his practices and games and analyzing the video.

[6] Lincecum attended Liberty Senior High School in Renton, Washington, where he played two seasons of varsity baseball.

[7] He was selected by the Chicago Cubs in the 48th round (1,408th overall) of the 2003 Major League Baseball (MLB) draft, but he did not sign, opting to attend the University of Washington instead.

[10][13] He was named a league all-star for Harwich, and posted a 2–2 record with a league-leading 0.69 ERA, striking out 68 batters in 39 innings.

[18] In the spring of 2007, Colorado Rockies prospect Ian Stewart described Lincecum as tough to face, saying "You can't see the ball at all until it's right on top of you.

"[19] Lincecum spent the first month of the season pitching for the Fresno Grizzlies, the Giants' Triple-A affiliate in the Pacific Coast League (PCL).

[21] After starter Russ Ortiz suffered an inflamed elbow, the Giants called Lincecum up to make his first career Major League start on May 6, 2007 at AT&T Park against the Philadelphia Phillies.

"[28] Lincecum was benched in September as a precaution due to the high number of innings he had pitched in his first full year of professional baseball.

Bruce Bochy, the manager of the Giants, told the San Francisco Chronicle that the team was being careful with Lincecum because of studies showing that pitchers who throw 200 innings in a season early in their careers are more susceptible to injuries.

[11] Against the Padres on September 8, Lincecum missed a regularly scheduled start for the first time in his major league career, due to back spasms.

On February 12, 2010, Lincecum signed a two-year, $23 million deal, breaking the previous arbitration record of $22,000,022 by Roger Clemens in 2006.

Facing one of the league's top pitchers, Ubaldo Jiménez, Lincecum pitched eight innings of one-run ball for his first win since July 30.

[11] On October 3 at AT&T Park, in a 3–1 win over the San Diego Padres, the Giants won the National League West Division title on the last day of the regular season.

[65] In his next postseason start, Lincecum outdueled fellow Cy Young Award winner Roy Halladay in a 4–3 victory over the Phillies in Game 1 of the NL Championship Series (NLCS).

[74] In Game 6 on October 23, with the Giants clinging to a one-run lead, Lincecum was summoned from the bullpen on one day's rest to pitch the bottom of the eighth inning.

[75] On October 27 at AT&T Park, in Game 1 of the World Series against the American League (AL) champion Texas Rangers, Lincecum committed what he called a "brain fart" in the first inning.

He struck out a franchise World Series record 10 batters in eight innings while giving up only three hits en route to a 3–1 victory.

[78] On May 4, Lincecum struck out twelve New York Mets, becoming the Giants franchise record holder for most games pitched with 10 or more strikeouts.

[80] On June 6 at AT&T Park, Lincecum struck out Washington Nationals third baseman Jerry Hairston Jr. swinging to end the top of the second inning for his 1,000th career strikeout, becoming the fastest Giants pitcher in franchise history to reach the milestone.

Lincecum was met with a large standing ovation from his loving fans as he came off of the mound and was congratulated by his coaches and teammates as he walked down into the dugout.

[121] He finally made an appearance in Game 2 of the 2014 World Series against the Kansas City Royals, entering to start the bottom of the seventh inning and retiring all five batters he faced.

[124] On May 20, in a 4–0 win over the Dodgers, Lincecum pitched seven shutout innings and passed Hall of Famer Carl Hubbell for fourth place in franchise history on the Giants all-time career strikeouts list.

[125] On June 27, Lincecum was hit in his pitching elbow with a line drive off the bat of DJ LeMahieu and left the game with an injury.

[139] In September 2019, Lincecum appeared at a postgame ceremony held by the Giants to mark Bochy's final game as the team's manager.

[160] While he was with the Giants, Lincecum lived in the Mission District area of San Francisco, steps away from the old Seals Stadium site.

Because of his "small size and unorthodox pitching delivery, he is an unlikely figure to have reached the pinnacle of his sport", which the Bee believes reflects the success of the Giants.

[169][170][171] On October 30, 2009, a police officer pulled Lincecum over in Washington for speeding and discovered the pitcher with 3.3 grams (0.12 oz) of marijuana, which was still illegal under state law at the time.

[173] San Francisco Giants fans made custom t-shirts that read "LET TIMMY SMOKE" with a pot leaf behind it and were sold online on eBay.

If you leave your name, number, and a short message, I'll be-" – only to be interrupted by Karl Ravech walking by and saying "Hey, Big Time Timmy Jim!

On January 25, 2017, Lincecum and over 100,000 attended a Women's March Rally in San Francisco, a day after the inauguration of President Donald Trump.