Wiese moved to Bundesliga side Kaiserslautern in the winter break of the 2001–02 season and initially played for their reserve squad in the third division and served as backup for Georg Koch and Roman Weidenfeller in the first team.

Following Reinke sustaining an injury in a match against VfB Stuttgart in February 2006, Wiese made his Bundesliga debut for Werder Bremen, and remained their first goalkeeper for the rest of the 2005–06 season.

Wiese, who is often compared to former German goalkeeper Oliver Kahn for his emotional outbursts, had a shaky start, with an error against Juventus in the second round of the UEFA Champions League on 7 March 2006 being of particular note.

With only two minutes of the game left to play, and Bremen on course to reach the quarter-finals, he made a routine catch, but then dropped the ball as he rolled on the ground, allowing Emerson to score and Juventus to progress.

[8] Following the signing of Heurelho Gomes from Tottenham Hotspur on loan at the end of January 2013, Wiese was dropped from the squad, with Hoffenheim's manager Andreas Müller stating, "Tim doesn't have a chance in the current situation.

[10] In March 2013, Müller announced that Wiese could leave the club on a free transfer if they were relegated,[11] prompting several of his teammates to come to his defence, including Weis and team captain Sejad Salihović.

[17] Wiese was a squad member for Germany in the 2010 FIFA World Cup, but was the only player not seeing any action as an understudy to Schalke 04 goalkeeper Manuel Neuer and was denied an appearance in the third-place playoff due to injury, enabling Bayern Munich veteran Hans-Jörg Butt to step in.

[22] Wiese made his professional wrestling debut at a WWE live event in Munich on 3 November 2016, teaming with Sheamus and Cesaro to defeat The Shining Stars and Bo Dallas.