The plot follows Heidecker and Wareheim, playing fictionalized versions of themselves, who are forced to re-open an abandoned mall to pay back a wasted billion-dollar loan.

The supporting cast includes Zach Galifianakis, Will Ferrell, John C. Reilly, Ray Wise, Twink Caplan, Robert Loggia, Jeff Goldblum, Bob Odenkirk, and Will Forte.

Tim and Eric decide to reinvent themselves as businessmen, dubbing their newly founded company Dobis PR, and depart Los Angeles to purchase the dilapidated mall from Weebs and renovate it, in the hopes that they will make back their billion-dollar debt.

While trying to refurbish the mall, they must deal with vagrants such as a mentally ill man-child named Taquito, bizarre stores (such as Reggie's Used Toilet Paper Discount Warehouse), and a man-eating wolf that stalks the food court.

[citation needed] Before the movie's release Tim and Eric started the Billion Dollar Pledge asking fans and celebrities to support them by signing a document stating they would not illegally download the film, and also not to see its box office competition The Lorax.

As part of it, they discussed the outline for the unproduced sequel, Trillion Dollar Movie, which would involve the duo being kidnapped by the dictator of an African country and forced to make a Saturday Night Live-style show.

The website's critics consensus reads: "Tim & Eric's Billion Dollar Movie is on a gleeful quest to repulse audiences, but sometimes less is more with this sketchy duo.

"[9] Variety gave the film a negative review, feeling that Tim and Eric "torture their purposefully inept, shortform sketch work into feature length...to diminishing returns" and that "fans of their Cartoon Network series or those simply familiar with the pair via YouTube will likely find the extended version of their pathos-and-pain-driven comedy hard to digest.

"[10] The Hollywood Reporter gave the film a negative review, stating "Auds attuned to Tim & Eric's weird wavelength will find plenty of guffaws in the first half, but a plot this thin can't sustain comedy based on discomfort.