It lies in the south of the province, at the confluence of the Paraná River and the Carcarañá River, 30 km north of Rosario and 144 km south of the provincial capital Santa Fe, on National Route 11.

Timbúes started as an agricultural colony in lands purchased by Camilo Aldao and former provincial governor José María Cullen, in 1868.

The settlement was officially acknowledged on 15 July 1871, and the first local authorities were elected on 2 September 1874.

In 1892, the Ferrocarril General Manuel Belgrano railway reached the colony, and the station received the name of Timbúes, which in time became the name of the town itself in popular use, though it was officially changed only in 1974.

The town is located at the northern end of the Industrial Corridor, an area with a great concentration of heavy and medium industries, as well as many important ports, that is centered in Rosario and reaches up to San Nicolás de los Arroyos.