Derijck is a product of the Anderlecht youth academy, but left the Brussels giants for Feyenoord before making it into the first team.

[1] He also wore the jerseys of Dender and NAC Breda before joining ADO Den Haag in January 2009.

[citation needed] On 15 August 2011, PSV Eindhoven announced the signing of Derijck on a four-year contract from ADO Den Haag for a fee of €750,000.

[citation needed] On 19 July 2013, it was announced that Derijck was sent on loan to FC Utrecht until the end of the season.

[6] On 5 September 2011, he received his first call up to the senior Belgium national team for the friendly match against the United States.