[29][30] In an open letter published by Time magazine in 2015, Knowles stated "I gave birth to two of you, but I have four incredible daughters" referring to Beyoncé, Solange, Kelly, and her niece Angie Beyincé.

[33] As a fashion designer, Knowles has been featured in publications such as Vogue, Cosmopolitan, Harper’s Bazaar, L'Officiel, InStyle, and Sports Illustrated.

She has also designed costumes for a number of films including Dreamgirls, Pink Panther, Austin Powers in Goldmember, Obsessed, and Cadillac Records.

In the early days of the group's career, she created outfits that the members wore on-stage and to events "out of necessity" because money was limited.

[43][44] In 2016, she made a cameo in Beyoncé: Lemonade, appearing in the visual for the song "All Night", which includes shots of her with then-husband Richard Lawson on their wedding day.

[45][46][47] In 2019, she appeared briefly in the background of a few shots in Beyoncé's Homecoming, a concert film about the singer's 2018 Coachella Valley Music and Arts Festival performances.

[53] On June 16, 2021, Knowles appeared in Facebook's Lift Black Voices Hub, in which she revealed what Juneteenth means to her family.

[54] In August 2021, it was announced that Knowles would be producing an upcoming program for Discovery, Inc. and the Oprah Winfrey Network, which aims to show the difficulties Black men face today, while highlighting and celebrating the triumphs and successes of everyday living.

[56] In December 2021, Knowles announced her show "Talks with Mama Tina" would begin airing on Facebook and include interviews with celebrities, such as Ciara and Zendaya.

[60] That same month, she had a role in the Lifetime thriller movie Wrath: A Seven Deadly Sins Story, starring Michelle Williams, Antonio Cupo and Romeo Miller.

[66] Knowles proposed the initiative, following the high number of deaths as a result of contracting the virus in the African-American community in Houston.

[68][69] Throughout the years, Knowles has supported movements promoting civil rights and opposing gender inequality in the United States, especially with regard to African Americans and the LGBT community.

[74] Knowles wrote an open letter to United States Senate leaders Mitch McConnell and Chuck Schumer, urging passage of the bill, with support from her daughters, Viola Davis, Whoopi Goldberg, Octavia Spencer and Jada Pinkett Smith.

[73] In 2017, Knowles and her then-husband Richard founded the Where Art Can Occur (WACO) Theater Center, a non-profit "dedicated to the empowerment of artists, and people in general" in Los Angeles.

[78] In 2001, Knowles was a recipient at the ACE Awards, which honors individuals who "help raise awareness of the accessories industry with a positive impact".