Known for her large-scale, musical, and ensemble-driven work, Landau's productions have appeared on Broadway, Off-Broadway, and regionally, most extensively at the Steppenwolf Theatre Company in Chicago where she is an ensemble member.

In 1997, she became a member of the Steppenwolf Theatre Company, where she has directed numerous productions including The Wheel, The Hot L Baltimore, Tarell Alvin McCraney's The Brother/Sister Plays and Head of Passes, The Tempest, The Time of Your Life (which later moved to Seattle Rep and A.C.T.

), The Diary of Anne Frank, The Cherry Orchard, Theatrical Essays, Time to Burn, Berlin Circle, and The Ballad of Little Jo.

Landau's many other regional credits include Antony and Cleopatra at Hartford Stage, A Midsummer Night's Dream at the McCarter Theater and Paper Mill Playhouse, Of Thee I Sing at Papermill, The Cure at Troy at Seattle Rep, Zack Zadek's Deathless at Goodspeed Musicals,[7][8] and the musical Dave at Arena Stage.

In addition to Floyd Collins, Landau's writing includes book and lyrics for Dream True and States of Independence, both with scores by Ricky Ian Gordon, the plays Beauty at La Jolla Playhouse (San Diego Critics Best Play), Space at Steppenwolf, the Public, and the Mark Taper Forum (TIME magazine Top Ten), Stonewall: Night Variations, and 1969 (or Howie Takes a Trip).

In 2025, she will return to direct a revised Broadway production of Floyd Collins at the Vivian Beaumont Stage at Lincoln Center, as part of their 2024-2025 season.